The short version of LC-MS/MS fits in a sentence. The long version — which is the one that helps — is below.
Reviewed 2025-08-17. Anything still debated is marked as such rather than presented as settled.
Laboratory samples of SR9009 are typically handled as research chemicals rather than pharmaceuticals. Suppliers usually state that the material is for research use only and not for human or veterinary administration. Storage recommendations generally call for a freezer at approximately −20 °C, protection from light, and a desiccated environment. The solid is often described as a white to off-white powder. Solubility is commonly reported in organic solvents such as dimethyl sulfoxide and ethanol, with low solubility in water.
Analytical identification and purity assessment often use high-performance liquid chromatography with ultraviolet detection or mass spectrometry. Liquid chromatography–tandem mass spectrometry is used to detect and quantify SR9009 in biological matrices, including urine and blood, for anti-doping or pharmacokinetic studies. Nuclear magnetic resonance spectroscopy can confirm molecular structure. Stability depends on form and storage: the solid is generally more stable than solutions, and repeated freeze–thaw cycles may degrade samples. Purity is typically reported as a percentage from a certificate of analysis.
SR9009 is a synthetic small molecule studied as an agonist of the nuclear receptors REV-ERBα and REV-ERBβ. It is not an approved medicine and has no established human therapeutic use. The compound appears in scientific literature as a tool for probing circadian and metabolic regulation. Online sellers often label it as a research chemical, sometimes using the nickname Stenabolic. Its chemical identity is distinct from selective androgen receptor modulators, stimulants, and peroxisome proliferator-activated receptor delta agonists. Researchers use it mainly in cell and animal experiments.
At the molecular level, SR9009 binds REV-ERBα and REV-ERBβ and alters their repressive activity on target genes. These nuclear receptors help regulate the circadian clock, lipid synthesis, glucose metabolism, and inflammatory pathways. By changing transcription, the compound can shift the timing or magnitude of downstream metabolic processes in model systems. It does not act through androgen receptors or adenosine receptors, which distinguishes it from several substances sold for athletic performance. Whether the same transcriptional changes occur in humans at tolerable exposures remains an open question because controlled human studies are lacking.
| Property | Value | Notes |
|---|---|---|
| Appearance | White to off-white powder | Common supplier description |
| Solubility | Soluble in DMSO and ethanol | Low solubility in water |
| Typical storage | −20 °C, desiccated, dark | For research samples |
| Analytical method | LC-MS/MS | Used for detection and quantification |
| Regulatory status | Prohibited in sport | WADA metabolic modulator class |
SR9009 is a synthetic small molecule studied as an agonist of the nuclear receptors REV-ERBα and REV-ERBβ, also called NR1D1 and NR1D2. These receptors help regulate circadian rhythms and metabolic gene programs. The compound was developed for laboratory research, not as an approved therapeutic. Its identity is distinct from steroid hormones and selective androgen receptor modulators. Scientific interest centers on how REV-ERB activation changes gene expression in cells and animal models.
At the molecular level, SR9009 binds the ligand-binding domain of REV-ERB and strengthens recruitment of corepressor proteins such as NCoR and HDAC3. This increases repression of target genes, including Bmal1 and other clock-controlled and metabolic genes. In rodent studies, such changes have been linked to altered lipid handling, glucose metabolism, and energy expenditure. The precise chain of events between receptor binding and whole-body effects remains an active area of research. Findings in animals do not automatically translate to humans.
SR9009 is a synthetic small molecule developed as an agonist of the nuclear receptors REV-ERBα (NR1D1) and REV-ERBβ (NR1D2). These receptors help regulate circadian rhythms and metabolic gene expression. In cell and animal studies, SR9009 alters transcription of genes involved in lipid metabolism, inflammation, and mitochondrial function. It is not an approved medicine, and its pharmacological profile in humans remains largely uncharacterized. The compound is frequently discussed in the context of circadian biology and metabolic research rather than clinical use.
Preclinical reports have linked SR9009 to improved endurance and altered energy expenditure in rodents. Such findings have prompted interest in whether REV-ERB activation can influence skeletal muscle metabolism. However, the reported effects depend on dose, route, and experimental model, and replication across laboratories is limited. Human trials have not established comparable outcomes, so claims about exercise performance remain speculative. The absence of controlled human data is a central limitation in interpreting these observations.
== Further reading == García-Colín, L.S.; Velasco, R.M.; Uribe, F.J. (August 2008). "Beyond the Navier–Stokes equations: Burnett hydrodynamics". Physics Reports. 465 (4): 149–189. Bibcode:2008PhR...465..149G. doi:10.1016/j.physrep.2008.04.010.
American Ornithologists’ Union Committee on Bird Collections ORNithological Information System (ORNIS) Type-specimens in 3D Extinct specimens in 3D (National History Museum of the Netherlands — Naturalis) Museum handbook Inventory of major European bird collections F.D. Steinheimer The whereabouts of pre-nineteenth century bird specimens Zool. Med. Leiden 79-3 (5), 30-ix-2005, 45-67.— ISSN 0024-0672. ebeac electronic index of bird collections
== Scientific implications and other uses == SPINA-GR significantly correlates with biomarkers for the allostatic load. The direction is negative, i. e., higher allostatic load is associated with lower insulin sensitivity. Together with the secretory capacity of pancreatic beta cells (SPINA-GBeta), SPINA-GR provides the foundation for the definition of a fasting based disposition index of insulin-glucose homeostasis (SPINA-DI). In combination with SPINA-GBeta and whole-exome sequencing, calculating SPINA-GR helped to identify a new form of monogenetic diabetes (MODY) that is characterised by primary insulin resistance and results from a missense variant of the type 2 ryanodine receptor (RyR2) gene (p.N2291D).
Sources: en.wikipedia.org
Provance, who ran a computer network used by military intelligence in the prison and who had been ordered not to speak to the press, told ABC News "Anything [the MPs] were to do legally or otherwise, they were to take those commands from the interrogators," and that the sexual humiliation began as a technique ordered by the investigators. He described several of the goings-on in the prison that he witnessed, such as the punching people in the neck hard enough to knock them unconscious after assuring them they weren't going to be hit, in order to catch them off guard. He also stated that Maj. Gen. George Fay, the Army's deputy chief of staff for intelligence, has shown little interest in investigating the interrogators and has gone only after the MPs, and that there is a culture of silence right now among those involved, who fear that if they say anything, the investigations will turn to them. On May 19, 2004, a court martial hearing was held for Cpl. Charles A. Graner Jr., who has been accused of being the ringleader of the group employing torture at Abu Ghraib. In an unexpected move, all three key witnesses - Lt. Col. Steven L. Jordan, Capt. Donald J. Reese, and contractor Adel L. Nakhla - refused to testify. This is an almost unheard of action. Under court martial proceedings, one cannot refuse to testify unless they have a belief that they will be exposed to criminal charges for doing so. Consequently, it is likely that the investigative proceedings will be forced to move higher up the chain of command.
Washing and sorting food source Juice extraction Straining, filtration and clarification Blending pasteurization Filling, sealing and sterilization Cooling, labeling and packing After the fruits are picked and washed, the juice is extracted by one of two automated methods. In the first method, two metal cups with sharp metal tubes on the bottom cup come together, removing the peel and forcing the flesh of the fruit through the metal tube. The juice of the fruit then escapes through small holes in the tube. The peels can then be used further, and are washed to remove oils, which are reclaimed later for usage. The second method requires the fruits to be cut in half before being subjected to reamers, which extract the juice. After the juice is filtered, it may be concentrated in evaporators, which reduce the size of the juice by a factor of 5, making it easier to transport and increasing its expiration date. Juices are concentrated by heating under a vacuum to remove water, and then cooling to around 13 degrees Celsius. About two-thirds of the water in a juice is removed. The juice is later reconstituted, a process in which the concentrate is mixed with water and other factors to restore any lost flavor from the concentrating process. Juices can also be sold in a concentrated state, in which the consumer adds water to the concentrated juice as preparation. Juices are then pasteurized and filled into containers, often while still hot. If the juice is poured into a container while hot, it is cooled as quickly as possible.
The Trump administration authorizes its ambassador to Lebanon Michel Issa to hold talks with Hezbollah. August 27 Incidents at Six Flags parks: The X2 roller coaster at the Six Flags Magic Mountain amusement park in Valencia, California, closes after two riders were recently hospitalized for brain injuries including hemorrhages. The US states it disrupted a Chinese hacking campaign that targeted the Justice Department, NASA, the Federal Reserve, the Senate, and other important government entities. Trump signs an executive order to rename Lake Ontario as "Lake America" in federal agency usage. August 28 Protests against Donald Trump: Demonstrators gather in Washington, D.C. at the March on Washington 2026: Defend the Vote rally to protest against the Trump administration's efforts to roll back voting and civil rights, 63 years after the March on Washington rally by Martin Luther King Jr. 2026–27 NHL season: In ice hockey, the Colorado Avalanche sign defenceman and alternate captain Cale Makar to an eight-year extension worth $163.2 million, the largest contract in National Hockey League history. He is the first player to exceed $20 million in AAV (average annual value). Trump announces the establishment of a "Space Academy" to train future civilian and military recruits. Richmond, Virginia removes the last three Confederate statues, with the three removed are statues of Stonewall Jackson, former Governor William Smith, and Hunter McGuire.
Sources: en.wikipedia.org
=== 1987 Goiânia, Goiás, Brazil === In the Goiânia accident of 1987, an improperly disposed of radiation therapy system from an abandoned clinic in Goiânia, Brazil, was removed, then cracked to be sold in junkyards. The glowing caesium salt was then sold to curious, unaware buyers. This led to four confirmed deaths and several serious injuries from radiation contamination.
1 by the Minister, after consultation with such bodies representative of those interests as he may think fit, to represent the interests of persons using bicycles and tricycles, not being motor vehicles, within the London Traffic Area. † An A Licence entitled the holder to drive a motorcycle; a B Licence a motor car; and a C licence a heavy goods vehicle. The Committee and Traffic Area were abolished in 1965 by the London Government Act 1963.
Official website Official news & press Burger King McLamore Foundation. Archived June 12, 2018, at the Wayback Machine. Liz's Legacy Cancer Fund BK Beat Cancer for Kids Business data for Burger King: Burger King at the Wayback Machine (archived March 24, 2002) "Burger King". Archived from the original on April 19, 2001. Retrieved December 9, 2013. "Burger King". Archived from the original on October 12, 1997. Retrieved May 18, 2005. "Burger King". Archived from the original on December 26, 1996. Retrieved November 10, 2016.
Sources: en.wikipedia.org
Legality depends on the country and the intended use. In many places it is sold as a research chemical, but sports and medicine regulations restrict it.
Detection commonly uses liquid chromatography–tandem mass spectrometry. This method can identify the compound in urine or blood at low concentrations.
Typical guidance is −20 °C, dry, and protected from light. Solutions should be aliquoted and limited freeze–thaw cycles should be used.
SR9009 is a synthetic REV-ERB agonist used in laboratory research. It is not an approved drug, and its effects in humans are not well characterized. It is often sold as a research chemical under the name Stenabolic.